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Methyl dopa

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Methyl dopa is a centrally-acting antihypertensive drug that is gradually declining in usage. It inhibits decarboxylation of dopa to dopamine. Therapy is associated with reduced concentrations of dopamine, 5 - hydroxytryptamine and noradrenaline in peripheral tissues and the CNS. This drug is associated with a reduction in renin levels.

Indications for the use of methyl dopa include:

hypertension, in conjunction with a diuretic
hypertensive crisis when an immediate effect is not necessary

Cautions/Contraindications:

history of depression
active liver disease
porphyria
phaeochromocytoma
increases the CNS toxicity of lithium

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Methyl dopa

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