Last reviewed 01/2018
A Lewy body is a neuronal inclusion body which is seen:
- in the substantia nigra in patients with idiopathic Parkinson's disease
- throughout the cortex in patients with dementia with Lewy bodies
- throughout the cortex in a subset who have a primary diagnosis of Alzheimer's disease
Inclusion bodies are typically aggregated protein, in the case of the Lewy body the major component is alpha-synuclein.