pathophysiology

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  • disorder that is principally mediated by antibodies to platelet antigens that leads to increased platelet destruction.
  • there is also relative marrow failure - this may be mediated by an effect of antiplatelet antibodies on megakaryocytes - platelet production is not appropriately increased in most patients.
  • most commonly autoantibodies are directed against epitopes on glycoprotein IIb/IIIa.

Last reviewed 01/2018