This site is intended for healthcare professionals
Login | Register (NOW FREE)

Medical search


FREE subscriptions for doctors and students... click here
You have 3 open access pages.

Disseminated intravascular coagulation (DIC) is a conditon where the physiological generation of thrombin becomes unregulated.

A wide variety of triggers may cause release of thrombin into the circulation with consequent formation of microthrombi. It is these thrombi that cause tissue ischaemia and necrosis.

In an attempt to maintain vascular patency the fibrinolytic system becomes activated. Unregulated fibrinolysis and systemic fibrinogenolysis occurs with release of plasmin into the circulation.

The unregulated generation of thrombin and plasmin results in the thrombotic and haemorrhagic features of DIC.


The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions LtdĀ®. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions LtdĀ® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook.