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Treatment

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The mainstay of treatment is intravenous amphoteracin B:

  • begin with a daily dose of 0.4 - 0.6 mg/kg
  • increase the dose to 1 mg/kg over a few days
  • aim for a total dose of 2-3 g

Unwanted effects are common, in particular the blood urea should be monitored; if urea becomes significantly elevated then amphoteracin should be stopped until renal function improves.

Addition of flucytosine (150 mg/kg) improves outcome, particularly in patients with AIDS.

Treatment should be for 6 weeks.

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