Last reviewed 01/2018
The mainstay of treatment is intravenous amphoteracin B:
- begin with a daily dose of 0.4 - 0.6 mg/kg
- increase the dose to 1 mg/kg over a few days
- aim for a total dose of 2-3 g
Unwanted effects are common, in particular the blood urea should be monitored; if urea becomes significantly elevated then amphoteracin should be stopped until renal function improves.
Addition of flucytosine (150 mg/kg) improves outcome, particularly in patients with AIDS.
Treatment should be for 6 weeks.