contraindications and precautions

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Contraindications include:

  • history of deep vein thrombosis or thromboembolism, endometrial or breast cancer, unexplained uterine bleeding
  • liver insufficiency including cholestasis
  • severe renal impairment

The SPC for raloxifene advises that cholestyramine should not be given with raloxifene - cholestyramine reduces the absorption and enterohepatic circulation of raloxifene.

Raloxifene may cause a modest increase in prothrombin time in patients receiving warfarin or other coumarins - this should be checked for.

The summary of product characteristics must be checked before prescribing this drug.

Last reviewed 01/2018