contraindications and precautions
- history of deep vein thrombosis or thromboembolism, endometrial or breast cancer, unexplained uterine bleeding
- liver insufficiency including cholestasis
- severe renal impairment
The SPC for raloxifene advises that cholestyramine should not be given with raloxifene - cholestyramine reduces the absorption and enterohepatic circulation of raloxifene.
Raloxifene may cause a modest increase in prothrombin time in patients receiving warfarin or other coumarins - this should be checked for.
The summary of product characteristics must be checked before prescribing this drug.
Last reviewed 01/2018