investigations in haemolytic disease of the newborn

Last reviewed 09/2022

If haemolytic disease of the newborn is suspected, the following investigations should be carried out:

  • full blood count, with attention to haemoglobin, white cells and reticulocytes
  • platelets
  • infant blood group and Coombs test
  • maternal blood group and haemolysins
  • red cell enzyme assay may be a helpful second line investigation
  • blood film and osmolar fragility may diagnose spherocytosis