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Investigations in haemolytic disease of the newborn

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

If haemolytic disease of the newborn is suspected, the following investigations should be carried out:

  • full blood count, with attention to haemoglobin, white cells and reticulocytes
  • platelets
  • infant blood group and Coombs test
  • maternal blood group and haemolysins
  • red cell enzyme assay may be a helpful second line investigation
  • blood film and osmolar fragility may diagnose spherocytosis

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