Glutamate dehydrogenase is an enzyme that interconverts glutamate into 2-oxoglutarate and vice-versa. The forward reaction converts NAD or NADP to NADH or NADPH. It also uses water and forms an ammonium ion and a proton.
The forward reaction is one example of oxidative deamination to interconvert an amino acid into a carbohydrate intermediate. Because the enzyme is near-equilibrium, the opposite reaction can occur if there is a reversal of the concentration gradient; this is termed transdeamination.
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