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seronegative spondarthritis

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Seronegative spondarthritis describes conditions, usually associated with seronegative polyarthritis, i.e. without serum rheumatoid factors, which may show changes in the sacroiliac and vertebral joints and ligaments that are indistinguishable from ankylosing spondylitis.

This group includes:

  • psoriatic arthritis
  • Reiter's disease
  • arthritis that accompanies inflammatory bowel disease
  • ankylosing spondylitis
  • Behcet's syndrome
  • Whipple's disease

This group of diseases share various characteristics:

  • all are associated with HLA-B27
  • the characteristic sacroiliitis and spondylitis occur in all of them
  • there is a familial aggregation
  • there is overlap between the different conditions, i.e. it is likely that more than one of these conditions may be present in the same family
  • negative rheumatoid factor tests


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