investigations
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- a skin or mucosal biopsy should be obtained for histology and direct immunofluorescence
- direct immunofluorescence of perilesional skin shows intra-epidermal
deposition of IgG between cells throughout the epidermis (1)
- direct immunofluorescence of perilesional skin shows intra-epidermal
deposition of IgG between cells throughout the epidermis (1)
- indirect immunoflourescence of serum is frequently positive, but is less
sensitive than direct immunofluorescence. It is useful in instances where
a biopsy is difficult to obtain e.g. - in children, uncooperative adults (1)
- ELISA - to detect anti-desmoglein 1 and anti-desmoglein 3 IgG autoantibodies (2)
Reference:
- 1. Harman K.E et al. Guidelines for the management of pemphigus vulgaris. BJD 2003; 149: 926-937
- 2. Stanley J.R, Amagai M. Pemphigus, Bullous Impetigo, and the Staphylococcal Scalded-Skin Syndrome. NEJM 2006; 355:1800-1810
Last reviewed 05/2021