LATE trial

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This trial assessed the role of thrombolysis in patients with ECG-diagnosed myocardial infarction who present more than 6 hr after the onset of symptoms.

Thrombolysis up to 12 hr post-onset of symptoms was associated with improved survival.


  • LATE Study Group. (1993). Late assessment of thrombolysis efficacy (LATE) study with alteplase 6-24 hours after onset of acute myocardial infarction. Lancet, 342, 759-66.

Last reviewed 01/2018