In Conn's syndrome there are high aldosterone levels in the absence of activation of the renin-angiotensin system.
- first described by Conn in 1955 in a patient presenting with resistant hypertension and hypokalemia who was found to have an aldosterone-secreting adrenal adenoma
- the adenoma is characterized by increased aldosterone secretion from the adrenal glands, suppressed plasma renin, hypertension, and hypokalemia
Classical Conn's syndrome should be considered in a patient who is not on diuretics who has the following features:
Sodium is usually mildly elevated or normal.
There is an increasing frequency in the diagnosis of primary aldosteronism (1):
- principal reason for the increasingly frequent diagnosis of this disease, once viewed as rare, is that normokalemic Conn's syndrome is now recognized as an independent disease entity
- normal serum potassium may be present in up to 38% of patients, especially in patients with adrenal hyperplasia or familial aldosteronism
- found in 5% to 18% of patients with high blood pressure
- Aronova A, Fahey TJ III, Zarnegar R. Management of hypertension in primary aldosteronism. World J Cardiol. 2014 May 26;6(5):227-33
Last edited 08/2021 and last reviewed 08/2021