Last reviewed 01/2018

Prednisolone is a synthetic glucocorticoid widely used for its anti-inflammatory and immunosuppressive actions. It is the most frequently used steroid for chronic prolonged oral therapy.

It has 400% of the anti-inflammatory potency of hydrocortisone but only 80% of its sodium-retaining ability.

In acute inflammation, an initial daily dose of 40-60mg may be necessary; if the desired response is obtained, the dose is reduced gradually over the course of a few weeks to a maintenance level of 5-15 mg.