intrinsic haemolytic anaemia

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Hereditary:

  • disorders of red cell membrane - for example:
    • hereditary spherocytosis
    • hereditary elliptocytosis
  • disorders of haemoglobin synthesis - for example:
    • sickle cell disease
    • thalassaemia
  • deficiencies of red cell enzymes - most commonly:
    • glucose-6-phosphatase dehydrogenase
    • pyruvate kinase

Acquired:

  • membrane defect - paroxysmal nocturnal haemoglobinuria

Last reviewed 08/2021

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