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International Stroke Trial

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The International Stroke Trial (IST) investigated the role of aspirin and/or heparin in the acute treatment of presumed ischemic stroke.

19,435 patients presenting within 48 hours with a diagnosis of ischaemic stroke were randomised to aspirin, heparin, both or neither. The trial was not blind.

The primary outcomes were:

  • death within 14 days
  • death or dependency at 6 months

The aim was to provide reliable evidence on the safety and efficacy of aspirin and of subcutaneous heparin.


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