Cisapride is a prokinetic drug that previously was licensed for gastro-oesophageal reflux, reduced gastric motility associated with a range of conditions, and non-ulcer dyspepsia.
This drug was withdrawn from marketing in the UK from 28th July 2000 until further notice . This is because cisapride can prolong the QT interval, which may lead to rare but life-threatening ventricular arrythmias. The committee on Safety of Medicines has advised that all treatment with cisapride should be stopped and patients should be changed to an alternative treatment as necessary.
- 1) Committee on Safety of Medicines (July 2000).Suspension of cisapride (Prepulsid): Product withdrawal.