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Clinical features

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

There is an incubation period of 2 to 10 days. Possible clinical features include:

  • abrupt onset of malaise, headache, myalgia and weakness
  • fever with rigor and temperature up to 40 deg.C appear 24 hours later after onset
  • cough - initially dry; becomes productive in half of patients; may be haemoptysis
  • half of cases develop gastrointestinal symptoms - nausea, vomiting, diarrhoea and abdominal pain
  • altered mental status - including confusion, lethargy, disorientation, hallucinations, depression, or coma
  • cranial and peripheral neuropathy not uncommon
  • crackles and consolidation - but the physical findings are mild compared to the radiological appearances
  • haematuria and occasionally, renal failure

Complications may include:

  • lung abscess
  • empyema
  • shock & hypotension
  • rhabdomyolysis
  • DIC
  • TTP
  • renal failure

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