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Production

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Histamine is produced by the action of histidine decarboxylase on histidine. It is stored in cells in granules in conjunction with acidic protein and a glycosaminoglycan. It is found in most tissues but in highest concentration in:

  • gastrointestinal tract, particularly the stomach
  • lungs
  • skin

Histamine is found in the following cells:

  • mast cells in connective tissues
  • basophils of blood; at lower concentration than in mast cells
  • platelets

The production of histamine in basophils is relatively slow in comparison to mast cells, particularly those in the stomach.


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