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Cornelia de Lange association

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Cornelia de Lange association includes:

  • multiple limb abnormalities, including:
    • phocomelia
    • oligo or polydactyly
  • synophrys
  • cleft lip and palate
  • downturning lower lip
  • cardiac anomolies - particularly ventricular septal defect
  • mental retardation
  • growth deficiency
  • microbrachycephaly


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