This site is intended for healthcare professionals
Login | Register (NOW FREE)

Medical search


FREE subscriptions for doctors and students... click here
You have 3 open access pages.

This is described as a disease that combines features of two or more of the following connective tissue disorders:

  • dermatomyositis
  • systemic lupus erythematosus
  • scleroderma

In mixed connective tissue disease there is a high incidence of:

  • Raynaud's phenomenon
  • myositis
  • arthralgia
  • erosive arthritis
  • hypergammaglobulinameia
  • oesophageal dysmotility

There is often a high titre against an extractable nuclear antigen (ENA - ribonuclear protein) and low titres against DNA.

The natural history of this condition is generally the slow evolution into one of the other inflammatory connective tissue syndromes, such as SLE, scleroderma or rheumatoid arthritis.


The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions LtdĀ®. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions LtdĀ® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook.