meta-analysis of St John's wort in depression

Last reviewed 01/2018

  • a meta-analysis of 27 trials comparing St John's wort with either placebo or active treatments was undertaken

  • this analysis suggests that St. John's wort is more effective than placebo and is as effective as low-dose tricyclic antidepressants (TCAs) as an antidepressant therapy

  • the mechanism of action appears to be the inhibition of the reuptake of noramines


  • 1) EBM (1999), 4(3), 82.