This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Type 2

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Type II is characterized by:

  • mesangial cell proliferation
  • electon-dense, linear deposits intramembranous deposits that usually stain for C3 only
  • C3 levels are reduced whilst C4 levels remain within the normal range - often associated with C3 nephritic factor, which causes alternative pathway complement activation (low C3 with normal C4)
  • recurs in transplants
  • light microscopy
    • enlarged glomeruli
    • lobulated due to mesangial cell proliferation
    • double contour basement membrane
  • E.M.
    • characteristic dense ribbon like deposits in lamina densa
  • immunofluorescence: C3 outlines glomerular B.M.

There is an association between mesangiocapillary glomerulonephritis and partial lipodystrophy; typically a female patient will have little subcutaneous adipose tissue above the waist.

Related pages

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.