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chronic granulomatous disease

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Chronic granulomatous disease is a condition where there is a deficiency in the ability of neutrophils to produce oxidant factors.

The result is an inability to lyse microorganisms, with consequent formation of abcesses; these are usually caused by staphylococci.

Inheritance is X-linked in about two thirds, autosomal recessive in the remainder.

Despite longterm antibiotic prophylaxis, survival to mid-teens is rare and most die by 5 years of age.

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