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Unconjugated hyperbilirubinaemia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Causes include:

  • increased bilirubin formation:
    • haemolysis
    • ineffective erythropoiesis:
      • megaloblastic anaemia
      • iron deficiency
      • haemoglobinopathies

  • failure of bilirubin uptake:
    • Gilbert's disease

  • failure of bilirubin conjugation:
    • neonatal jaundice
    • Crigler Najjar syndrome
    • drug inhibition e.g. chloramphenicol
    • extensive hepatocellular disease e.g. hepatitis, cirrhosis

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