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POEMS syndrome

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POEMS is an acronym for:

  • polyneuropathy:
    • slow onset of mixed motor and sensory polyneuropathy
    • peripheral nerve demyelination with some axonal degeneration

  • organomegaly:
    • hepatosplenomegaly

  • endocrinopathy:
    • gynaecomastia
    • secondary amenorrhoea
    • diabetes mellitus
    • hypothyroidism

  • monoclonal protein

  • skin changes:
    • hyperpigmentation
    • hypertrichosis
    • skin thickening

The underlying pathology is usually an osteosclerotic myeloma. Radiographic surveys often reveal a single osteosclerotic lesion in the spine or proximal long bones.


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