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Sjogren's syndrome

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Primary Sjogren's syndrome is the association of

  • keratoconjunctivitis sicca and/or xerostomia, with
  • rheumatoid arthritis or other connective tissue disorder

Salivary gland biopsy shows sialadenitis. Involvement of other secretory glands is common causing dyspareunia, dry skin, dysphagia, otitis media and pulmonary infection.

Other features include dental caries, attacks of monilial stomatitis, neuropathy, hepatosplenomegaly and renal involvement.

Associations include renal tubular acidosis, adverse drug reactions and lymphoma. Secondary Sjogren's occurs in about 50% of cases of rheumatoid arthritis.


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