pharmacokinetics

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  • plasma concentration peaks within 2 hours after oral administration

  • half-life is approximately 13 hours

  • absorbed drug mainly protein bound (at least 90%)

  • reboxetine is mainly metabolised by the liver

  • there is evidence that elimination is slowed and systemic exposure increased, in patients with hepatic and renal impairment and in elderly patients

Reference:

  • Drug and Therapeutics Bulletin (1998), 36 (11), 82-4.

Last reviewed 01/2018