Helicobacter pylori

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Helicobacter pylori (formerly named Campylobacter pylori) is a gram negative S shaped or spiral bacillus, described as a Unipolar flagellate, 1 by 3 micrometres in size. It is a microaerophilic, and produces urease and other toxins.

Infection with Helicobacter pylori is common in patients with peptic ulceration. A short course of standard ulcer treatment usually heals ulceration but about 85% of patients relapse within a year. In patients with duodenal ulcer, eradication of H. pylori causes the relapse rate to fall to 0 - 20%.

The best test for identification of H Pylori and for confirmation of eradication is the 13C urea breath test (1).

Reference:

  1. BSG (2002) Dyspepsia management guidelines.
  2. Drugs and Therapeutics Bulletin (1993); 31(4) 4: 15.

Last reviewed 06/2021

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