Myelosuppression is the dose-limiting side effect of all antibiotic chemotherapeutic agents except bleomycin where the dose-limiting side effects are neurological and dermatological.
The nadir of platelet and granulocyte count is generally 10-15 days after treatment (note though that it is 28 days following treatment with mitomycin). Mucositis is also maximal at this time.
Other toxic effects include:- - potentiation of local effects of irradiation. Also a radiation 'recall' phenomenon may be seen. - cardiac toxicity eg anthacycline antibiotics
Note that derangement in kidney or liver function can enhance the toxic effects of these drugs in normal tissues.
Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page