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Pathology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Most cases of haemolytic uraemic syndrome are associated with diarrhoea and occur in children. These cases, in general, have a natural history where there is complete recovery and there is usually no renal biopsy taken.

Diarrhoea-associated HUS characterised by:

  • glomerular capillary thrombosis
  • some arteriolar thrombosis and necrosis

Idiopathic HUS:

  • generally occurs in adults
  • show a preglomerular pathology with intimal proliferation and luminal stenosis affecting arterioles and small arteries
  • in 10% of adult cases there are no pathological changes seen in the glomeruli or vessels and the only lesion seen is acute tubular necrosis (1)

Reference:

  • (1) Neild GH (1993). Haemolytic uraemic syndrome in practice. Lancet, 343, 398-402.

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