hepatitis B virus hepatitis
Hepatitis B infection is a serious and common infectious disease of the liver caused by the hepatitis B virus (HBV) (1)
- HBV is an enveloped DNA virus. The complete virus particle is known as the Dane particle and has characteristic serological markers
- it transmitted parenterally, or by intimate, usually sexual contact (1).
Hepatitis infection can be either:
- occurs in 1-4% of hospitalised patients with HBV, a figure which is increased by concomitant infection with hepatitis D virus
- usually a self-limiting disease marked by acute inflammation and hepatocellular necrosis
- case fatality rate is around 0.5–1%
- defined as persistence of hepatitis B surface antigen (HBsAg) for six months or more
- chronic sequelae are attributed to deficiency in the host immune response rather than to the cytotoxicity of HBV
- encompasses a spectrum of disease (1)
- (1) World Health Organization (WHO) 2015. Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection.
- (2) NICE (October 2017). Hepatitis B (chronic) Diagnosis and management of chronic hepatitis B in children, young people and adult
Last edited 06/2018 and last reviewed 07/2018