Chronic autoimmune hepatitis is a chronic hepatitis of unknown origin that predominantly affects young and middle aged women. It is associated with HLA types A1, B8, DR3 and Dw3.
There are reduced numbers of T-suppressor cells which results in the production of autoantibodies against hepatocyte surface antigens.
The condition may be referred to as lupoid hepatitis as a positive LE cell test occurs in about 15% of patients. However, the condition is distinct from classical systemic lupus erythematous.