clonidine in the treatment of menopausal symptoms
Last edited 02/2020 and last reviewed 03/2020
- there is evidence that clonidine improves the symptoms of menopausal hot
flushes in approximately 40% of women (1)
- clonidine is often used as a first-line treatment
in a dose of two or three 25μg tablets twice daily (2)
- a maximum of 75 micrograms bd or
50mcg tds should be used (3)
- however side effect with clonidine treatment are common and include dizziness, irritability, nausea and dry mouth
- interaction with anti-hypertensive drugs and not suitable for patients with baseline low blood pressure
- must be reduced gradually otherwise
causes rebound hypertension (3)
- dose related side-effects include sleep disturbance in at least 50% of patients, dry mouth nausea and fatigue (3)
- clonidine is often used as a first-line treatment in a dose of two or three 25μg tablets twice daily (2)
The summary of drug characteristics should be consulted before prescribing this drug.
- Laufer LR et al (1982). Effect of clonidine on hot flushes in postmenopausal women. Obstet Gynecol, 60, 583-6.
- Grady D. Clinical practice. Management of menopausal symptoms. N Engl J Med. 2006;355(22):2338-47.
- British Menopause Society. Prescribable alternatives to HRT (Accessed 12/2/2020).
- Prescriber (2001), 12, 13 (5), 47-58.