clonidine in the treatment of menopausal symptoms

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  • there is evidence that clonidine improves the symptoms of menopausal hot flushes in approximately 40% of women (1)

    • clonidine is often used as a first-line treatment in a dose of two or three 25μg tablets twice daily (2)

    • a maximum of 75 micrograms bd or 50mcg tds should be used (3)

    • however side effect with clonidine treatment are common and include dizziness, irritability, nausea and dry mouth

    • interaction with anti-hypertensive drugs and not suitable for patients with baseline low blood pressure

    • must be reduced gradually otherwise causes rebound hypertension (3)

    • dose related side-effects include sleep disturbance in at least 50% of patients, dry mouth nausea and fatigue
    • (3)

The summary of drug characteristics should be consulted before prescribing this drug.

Reference:

  1. Laufer LR et al (1982). Effect of clonidine on hot flushes in postmenopausal women. Obstet Gynecol, 60, 583-6.
  2. Grady D. Clinical practice. Management of menopausal symptoms. N Engl J Med. 2006;355(22):2338-47.
  3. British Menopause Society. Prescribable alternatives to HRT (Accessed 12/2/2020).
  4. Prescriber (2001), 12, 13 (5), 47-58.

Last edited 02/2020 and last reviewed 03/2020

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