nRNP autoantibody

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This is antibody to a cytoplasmic ribonuclear protein complex

nRNP antibody

  • target U1-RNP
  • positive in 15% systemic sclerosis
  • clinical association
    • overlap features of SLE, arthritis
      • associated with mixed connective disease and SLE with particular features (arthritis, myositis, Raynaud's phenomenon - also association with HLA-DR4 and HLA-DQw8)


  • 1) Arthritis Research Campaign (2010). Topical Reviews - Systemic sclerosis and related disorders.

Last reviewed 01/2018