effects

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PAF can produce a range of inflammatory phenomena, even at low concentration; some responses are concentration-dependent:

  • at low concentration, vasodilatation; at higher concentration, vasoconstriction
  • increased venular permeability
  • platelet aggregation and degranulation
  • neutrophil aggregation, endothelial adhesion and chemotaxis
  • smooth muscle contraction in lung and gastrointestinal tract
  • synthesis of other mediators e.g. prostanoids, and synergism with their effects

Hence, administration of PAF to animal models can produce effects varying in severity between localised inflammation and anaphylactic shock.

Last reviewed 01/2018