low molecular weight heparin for acute ischaemic stroke

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Low molecular weight heparin has been trialled for the treatment of acute ischaemic stroke:

  • 312 patients within 48 hours of onset of ischaemic stroke
  • randomised to 4100 U of LMWH once or twice daily or placebo
  • treated for 10 days
  • followed for 6 months

The rates of mortality or dependency at 6 months were:

  • 45% for the twice daily LMWH group
  • 52% for the once daily LMWH group
  • 65% for the placebo group

The rates of haemorrhagic transformation were the same.


  • Kay, R. et al. (1995). Low-molecular-weight heparin for the treatment of acute ischemic stroke. NEJM, 333, 1588-93.

Last reviewed 01/2018