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Aprotinin

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Aprotinin is an enzyme which causes proteolysis of plasmin and kallikrein, so promoting haemostasis.

It is indicated for:

  • patients undergoing open heart surgery with circulatory bypass where control of haemorrhage is vital
  • hyperplasminaemia severe enough to promote massive haemorrhage e.g secondary to excessive thrombolytics

It is given by slow intravenous infusion or injection. Complications include hypersensitivity and local thrombophlebitis.

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