This site is intended for healthcare professionals

account_circleSign in
Go to /sign-in page

You can view 5 more pages before signing in

Drug interactions

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Sulphonylureas are subject to a number of interactions although these are rarely important clinically. There hypoglycaemic effects can be altered by:

  • pharmacodynamic interactions with:
    • glucocorticoids
    • beta-blockers

  • pharmacokinetic interactions by 3 mechanisms:
    • reduction in renal elimination for example by allopurinol
    • reduction or acceleration of hepatic metabolism by cimetidine, or carbamazepine and phenytoin, respectively
    • displacement from protein binding sites - sulphonylureas are up to 99% protein bound - for example by salicylates

Related pages

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page