This site is intended for healthcare professionals
Login | Register (NOW FREE)

Medical search


FREE subscriptions for doctors and students... click here
You have 3 open access pages.

  • a stereoisomer of amphetamine (amfetamine) - has greater stimulant properties than amphetamine (amfetamine)
  • licensed indications include for treating childhood hyperactivity where non-pharmacological measures have proved insufficient - there is evidence that treatment with dexamfetamine (or methylphenidate) relieves the symptoms of severe hyperactivity in children, at least, in the short-term (1)
  • dexamfetamine is also used in the treatment of narcolepsy
    • however there are few published controlled trials assessing dexamfetamine in patients with narcolepsy (2)
      • in one double-blind crossover trial, dexamfetamine (30mg daily for 4 weeks) roughly halved "sleep attacks" (from 4.4 to 2.2 per day, p<0.01)
  • dexamfetamine can cause dependence and tolerance (and in the UK, it is classified as a Controlled Drug), and so some doctors and patients may be reluctant to use it (2)
  • adverse effects include:
    • emotional lability, insomnia, reduced appetite
    • there have been reports of growth retardation with long-term use - this effect can be reduced by using drug-free periods; also effect does not appear to affect final adult weight and height
    • rare effects - seizures, compulsive behaviours, psychotic reactions, persistent dysphoria, lack of spontaneity
  • dexamfetamine is contraindicated in patients with moderate to severe hypertension.

The Summary of Product Characteristics must be consulted before prescribing this drug.


  1. Drug and Therapeutics Bulletin 2001; 39(7):52-54.
  2. Drug and Therapeutics Bulletin 2004; 42(7):52-56.


The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions LtdĀ®. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions LtdĀ® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook.