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Clinical adverse events on methotrexate

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • mouth ulcers
  • stomatitis

Stop if severe, reduce dose if mild/moderate. Consider carbenoxalone or difflam mouth washes. Consider other causes.

  • cough or dyspnoea

Stop drug. Seek advice. Chest X-ray and pulmonary function tests.

  • nausea/anorexia

Split dose, reduce dose. Take with food. Try anti-emetic. Stop if unacceptable

  • increased nodule formation

Reassure. Stop if unacceptable

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