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Clinical pharmacology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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  • stabilises neuronal membranes and reduces the release of excitatory amino acids, especially glutamate, by blocking voltage-sensitive sodium channels
  • rapid and complete absorption after oral administration
  • metabolised in the liver, largely by glucorinidation, and has an elmination half-life of 25-30 hours
  • about 55% protein-binding

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