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Conditions associated with paediatric malignancy

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

There are five categories of conditions which increased an individual's probability of malignant disease. Some of the conditions are listed below:

General:

  • Beckwith Wiedemann syndrome
  • hemihypertrophy
  • multiple exostosis
  • neurofibromatosis

DNA repair defects:

  • ataxia telangiectasia
  • Fanconi anaemia
  • xeroderma pigmentosa

Immune deficiency disorders:

  • common variable immune deficiency
  • severe combined immune deficiency
  • Wiskott Aldrich syndrome

Chromosomal abnormalities:

  • 11p13 deletion (Wilms' tumour)
  • 13q14 deletion (retinoblastoma)
  • trisomy 21 (Down syndrome)

Familial syndromes:

  • familial adenomatous polyposis
  • familial Hodgkins disease

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