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Dosage of methotrexate

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Consult expert advice. Specialist knowledge is required if managing the initiation and monitoring of patients on methotrexate.

  • start at 5mg or 10 mg oral or IM WEEKLY
  • folic acid 5 mg oral weekly, 3 days after methotrexate reduces adverse reactions
  • if inadequate response dose may be increased upto 20 mg weekly
  • total duration of treatment as long as clinically indicated

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