Korsakoff's psychosis

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Korsakoff's psychosis is a condition that is characterised by a retrograde amnesia - loss of memory for events before the onset of the illness - and an inability to memorise new information.

The condition is most commonly seen in alcoholics where there is loss of nerve cells in the thalamic and mamillary bodies secondary to a thiamine deficiency, and occasionally in cases of head injury, cerebral hypoxia, tumour or encephalitis. There is microglial and capillary proliferation.

Last reviewed 05/2021

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