The prime indication for its use is in tuberculosis.
Caution should be exercised when using it in the presence of:
- history of psychosis
- impaired liver and kidney function
- breast feeding
- drug-induced liver disease
Side-effects of isoniazid include:
- peripheral neuropathy with high doses or in patients with pyridoxine deficiency
- psychotic episodes
- nausea and vomiting
- hypersensitivity reactions including rashes
- SLE like syndrome
Routes of administration:
- i.m. injection
- i.v. injection
The summary of product characteristics should be consulted before prescribing this drug.