liver diseases causing asymptomatic elevation of ALP

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Liver diseases which may cause asymptomatic chronic elevation of alkaline phosphatase include:

  • chronic cholestatic liver disease:
    • partial biliary obstruction
    • primary biliary cirrhosis
    • primary sclerosing cholangitis
    • drug-induced e.g. anabolic steroids

  • chronic infiltrative liver disease:
    • sarcoidosis
    • malignant metastasis

Last reviewed 09/2019