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Interactions

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • another DMARD - leflunomide should not be concomitantly administered with another DMARD

  • alcohol - this is because of the potential for additive hepatic side effects - therefore alcohol should be avoided whilst on treatment with leflunomide (1)

  • the manufacturer advises caution when concomitantly prescribed with drugs that are metabolised by the cytochrome P4502C (e.g. tolbutamide, warfarin, phenytoin)

  • a live vaccine should not be administered if a patient is currently, or has recently received, treatment with leflunomide

Check manufacturer's information for latest prescribing information.

Reference:

  • 1) Drug and Therapeutics Bulletin (2000), 38 (7), 52-4.

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