This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Raltitrexed

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Raltitrexed is an inhibitor of thymidylate synthase. It is licensed for use as monotherapy when fluorouracil-based palliative therapy for colorectal cancer is inappropriate or not tolerated (1).

Adverse effects:

  • raltitrexed is more likely than infused fluorouracil/folinic acid to cause severe nausea, diarrhoea, anorexia, lethargy, neutropenia and thrombocytopenia (1)
  • if raltitrexed is used then monitoring of renal function is essential (dose should be adjusted if creatinine clearance is below 65 mL/minute) (1)

Reference:

  1. Drug and Therapeutics Bulletin (2002), 40(7), 50-2.

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page