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Passive cutaneous anaphylaxis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Passive cutaneous anaphylaxis in mice is a model of type I hypersensitivity reactions:

  • a non-sensitized mouse is given a subcutaneous injection of IgE-containing serum from an allergen-sensitized mouse

  • subsequent administration of the allergen results in a characteristic localised wheal and flare reaction called the Prausnitz-Kustner reaction

The Prausnitz-Kustner reaction provides evidence for the role of IgE in type I hypersensitivity reactions.

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